Tuberculosis is one of the most contagious diseases in the world, organized with the help of the relevant bacteria of the family of Mycobacterium tuberculosis – thus claiming more than 1.5 million lives each year. Despite the fact that at this point in time, tuberculosis is almost completely treatable, it is still not so easy to defeat its key parent bacterium, primarily because it has the ability to quickly overgrow with a protective biofilm, thus preventing its destructive action. from modern antibiotics. However, a team of experts from the United States found a way to bypass this protection.
And the method itself is to prevent the very property of this bacterium to form a protective biofilm around itself. To begin with, the team of researchers analyzed more than 91 chemical compounds whose chemical structure is closest to the aforementioned tuberculosis bacterium, and whose effectiveness has already been tested repeatedly in combating other dangerous bacteria.
And they did find the most promising compound called C10, which just focuses on preventing the bacteria from acquiring a protective biological film, with which it copes at the proper level, which was tested during the tests in the laboratory. Moreover, in their own laboratory tests, experts decided to add some of the substance C10 to a certain number of antibiotics that fight against similar bacteria, such as isoniazid. After conducting the second stage of their clinical studies, the specialists actually managed to largely destroy most of the bacterial colonies.
Thus, they proved that such a combo of substance C10 and any more or less potent antibiotic is sufficient to effectively fight and destroy even the most protected colonies of tuberculosis bacteria, because the substances weaken their natural defense and allow the antibiotic to carry out their work. Thus, it remains only to wait for the moment when the development will be further improved for the conduct of clinical tests.