The mechanisms of neurons continue to amaze scientists

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Specialists from the University of Toronto and the University of Cambridge today published a new article about a unique study devoted to the analysis and disclosure of a newly discovered mechanism of neuronal death in amyotrophic lateral sclerosis or some forms of dementia – an article with the study has already been published in the journal Cell. A key element of the study here is the study of special protein compounds called FUS, which play the role of both an RNA transporter for the production of new proteins, and along with this, the role of a producer of new synapses between individual neurons and neuron blocks in the brain.

Scientists decided to focus on the functions and features of FUS proteins in order to establish by which mechanism the death of many neurons as a result of the development of dementia or amyotrophic lateral sclerosis. Using human and frog cells for neural research, experts found that the process of reformatting FUS proteins is strictly controlled by special enzymes that determine the fate of the proteins and RNA cells themselves. In the case of amyotrophic lateral sclerosis, experts found that FUS proteins pass through an irreversible process of internal mutation and thus cease the ability to transform to carry RNA.

In the case of prefrontal dementia, approximately the same process occurs, but with a slight difference – FUS proteins also change their chemical modifications in working with other brain cells.

Thus, specialists were able to not only discover which mechanism underlies such a fast pace of neuronal death in dementia and lateral sclerosis, but also to identify additional biological agents and factors contributing to this. Of course, scientists have yet to conduct a lot of tests and determine the most convenient medical diagnostic model, but there is no doubt in the really high level of results!

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