News & Events
Scientists experiment with antibiotic derived from aspen poison
- October 31, 2019
- Posted by: Wiley M. Wagner
- Category: Science
As bacteria in the world become more and more resistive in relation to antibiotics – including the most effective and strongest variants – scientists are becoming increasingly aware of the need to create new, more effective types of antibiotics. And for this they pay attention to those sources of their manufacture, which at first glance seem not quite successful – for example, the poison of certain species of wasps. It was this approach that was chosen by specialists from the Massachusetts Institute of Technology, who decided to study different configurations of the poison of the African wasp of the family Polybia paulista and were not disappointed in this sense.
It is known that the poison of various insects and animals as a whole has its own structures of natural antibiotics and peptides – white connected structures – which can effectively fight emerging infections and bacteria. However, the isolation and use of these peptides for humans becomes somewhat dangerous, due to their natural toxicity. To this end, MIT experts decided to create their own configurations of one of the peptides found in African wasp venom – which consisted of 12 amino acid chains – and thus test it on grown human liver cells.
After quite lengthy experiments and reconfigurations, they were able to synthesize several variants of such an antibiotic, and the least toxic ones were tested on experimental rats infected with Pseudomonas aeruginosa bacteria – and one of the antibiotic variants managed to completely cure some of them from this bacterium within four days.
This successful result clearly reflects the possibility and promising nature of the use of this modified natural aspen antibiotic in modern antibacterial drugs – of course, specialists have yet to further stabilize the formula, but in its current form, this antibiotic works very effectively!