The ability to gradually introduce the necessary substances into the patient's body for the treatment of a particular disease is not as simple as it might seem at first glance – even if it comes to the use of so-called ointments that can constantly release the necessary substances under the skin. It was with the goal of creating a conceptually new type of such an intelligent medicine that can independently and, most importantly, a follower release the necessary substances and groups of substances into the human body, a team of researchers from the Technical University of Munich presented its new study on the development of such a drug concept, which has already been demonstrated really high level of efficiency.
The basis of the new smart drug is the use of two main components – a specially created hydrogel and an edited segment of artificial DNA, which serves as a holder of substances stored in it.
The hydrogel itself forms a specific format for such a drug, within which various substances are released on a sequential basis. As an experiment, scientists used silver, copper oxide and gold nanoparticles, and it was in this sequence that they stood out. Thanks to the external editing of the behavior of artificial DNA – inside which these nanoparticles were enclosed – the scientists were able to correctly configure the trigger reaction of DNA, which, as it degrades and decreases, the follower gradually isolated these nanoparticles from the hydrogel. Preliminary results of the study demonstrated that scientists actually managed to create a conceptually new and, most importantly, an effective way to isolate such substances.
So very soon, a team of researchers will begin to test their development on experimental mice – because their biology is largely similar to human. Although, of course, at this point in time there are quite a few questions and issues related to the implementation of this development on a larger scale – and this will depend on how much it takes root in the world.