Liver metabolism can be altered to counter diabetes

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Many modern people know firsthand, at least in general terms, how to eat and stay healthy – but those who love food rich in fats and sugar are often interested in various trade-offs. So the microbiologists from the Max Planck Institute, specializing in the study of the features and metabolic schemes of internal organs, decided to create an interesting experiment on mice, aimed at determining whether it is possible to consume such dangerous products and still remain healthy. The test results surprised many experts themselves.

The fact is that the consumption of large amounts of fat and sugar leads to the expansion of adipose tissue and the fats themselves in the body, which cover the internal organs and significantly reduce the level of response to insulin – and this can cause type 2 diabetes and other diseases of a similar spectrum. And these diseases are formed by the action of the so-called ceramides – special fats that regulate this process.

The researchers, using the example of rodents, tried to find out whether it is possible to block the process of their synthesis in the body in order to continue to consume a fat-rich diet and stay healthy. After several test sessions, they found that turning off one of the synthesizing processes in the liver — the so-called 6th type of ceramide synthesis — can actually lead to significantly faster absorption of fats and sugars. The rodents with which these modifications were made showed a higher level of physical activity and general health despite the fact that they consumed a lot of fat.

Thus, the specialists actually managed to significantly change the fatty metabolism of the liver, while achieving more than solid and stable results in terms of the absorption of fat and ceramides. So far it is unclear what the results will be for people, but the current study and its results clearly demonstrate that, in the future, a change in metabolism may become one of the most common medical practices.

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