Laser technology helps improve microscopy

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Developing new methods and approaches for the diagnosis of cancer and the presence of cancer cells in general, many researchers and technicians often forget that their new approach has objective and very specific shortcomings and weaknesses. However, given the successes that oncological diagnostics specialists from the Caltec Research Center in the USA have managed to achieve, it becomes clear that their research is one of the most promising in this regard. And all because specialists were able to significantly improve the existing technique for detecting cancer cells in the human body.

We are talking about the so-called PAM scan, which stands for photoacoustic microscopy, which is used directly in the scanning session. Unlike many more traditional and common types of scanning, such as position-emission tomography and fluorescence tomography, PAM scanning involves the use of a laser to induce vibration and audio waves in a single study area.

Now, specialists from Kaltek have managed to significantly improve this laser diagnosis by adding some additional microscopic sensors that measure the level of oxygen absorbed and released by the cells themselves – and cancer cells, as you know, have a more dynamic metabolism compared to healthy cells, which allows us to find they are faster with this approach. However, development experts also say that most likely they will have to reconsider in the very near future an objective approach to the application of this kind of oncological diagnosis, since it also has some weaknesses.

For example, the impossibility of rapid detection of microparticles of cancerous tumors even when using multiple oxygen sensors during PAM scanning. And secondly, specialists need to find a way to reduce the number of oxygen microsensors, ideally creating a pair of sensors that can effectively capture the largest possible area of ​​study of potentially affected areas.

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