Irritability and related brain conditions are really a big problem if they are chronic – and while traditional methods and therapies do not always help, specialists from different universities and research centers are working on new ways to get rid of irritability. So the team of neuroscientists from the Max Planck Institute presented their new project aimed at combating one specific protein, which, according to scientists, is the main culprit in enhancing various brain pathologies in the context of feelings.
We are talking about the protein lgSF9b, which is located in the almond part of the brain and which has been studied by a team of specialists for a long time – they believe that this gene is the main culprit in the emergence and amplification of various emotional pathologies of a chronic nature.
During experiments on experimental mice, they found that the protein really is a kind of bridge between the synapses, activated by it and thus leading the brain to certain emotional states. Scientists, after inducing irritability to mice, decided to test their theory and blocked the activity of this protein – as a result of the study, they noticed that the behavior of the mice changed to a calmer one and they began to demonstrate a fairly stable emotional level regardless of situations. Thus, their work proves that new methods of therapy should be based on the point effect of certain genes and proteins.
So far, the research project of specialists from the Max Planck Institute is undergoing additional checks and replenished with new features that were previously undiscovered. However, if we talk about a specific result, then specialists intend to continue to work in this direction in order to develop new, more effective methods of therapy and methods of influencing various groups of proteins in the brain.