News & Events
Found anti-CRISPR blocking molecule
- May 7, 2019
- Posted by: Wiley M. Wagner
- Category: Science
As mankind plunges deeper and deeper into the wonderful world of genetic technologies and technologies related to the operation of the CRISPR system, it is becoming increasingly aware of the need to develop and improve special compounds and molecules that can withstand such genetic engineering – for a variety of needs. That is why a team of genetic research specialists from Brigham University in the UK today presented the results of their long but fruitful research on the analysis of the most suitable candidates for the role of molecules that can effectively block the intervention of CRISPR technology.
Initially, specialists made up a kind of meta-research base of various groups and types of proteins and protein compounds that could potentially quickly and effectively penetrate CRISPR cells and stop the effect of this technology. Despite the fact that even earlier they found several of the most appropriate proteins, they still have certain limitations, mainly because of their large size, which does not allow them to easily penetrate into the cells.
Of the more than 15,000 protein combinations, scientists this time were able to isolate one of the most multifunctional and reliable molecules called BRD0539, which has the ability to inhibit the Cas9 enzyme, which is the main enzyme for working with CRISPR technology, to connect to the smallest DNA segments. CRISPR technology, thus, becomes really interesting and unusual for the most diverse field of activity, and the blocking protein BRD0539 is the best blocking tool.
The development and testing of such a tool is really important, and therefore, experts are trying hard to work out the concept in an additional way – and therefore we can expect that very soon the company of scientists will attempt to further improve and expand the functionality of this blocking protein – especially that there are many interesting aspects.