The brain is a rather funny and unusual thing in modern science of neurobiology, and in particular it is unusual because it describes almost all the major and minor processes that occur with us and our bodies in the process of aging. Recently, neuroscience specialists from Stanford University made a new attempt to identify similarities and patterns associated with neurodegeneration and the work of certain genes – and found that brain aging can actually be slowed down, mainly by using special antibodies on microglia – a special type brain cell cleaners of extra proteins.
Scientists made up several groups of experimental mice, which tracked a variety of genetic combinations and variants of genes, which in their preliminary opinion could be associated with the work of the brain and its aging process. The fact is that microglia are mainly engaged in the collection and utilization of large amounts of proteins, whose accumulation often leads to certain neurodegenerative symptoms and diseases.
Having flown through more than 3,000 genetic combinations and making a parallel study in another group of rodents, scientists were surprised to find out that in all cases only a single gene, called CD22, is present, which is responsible for correct microglial process and for weakening brain aging. Then, experimentally, with the help of a Petri dish and some laboratory equipment, they were able to create a prototype agent-antibody, which, acting on this gene, can literally update its function in the process.
As a result of the application of this experimental antibody in mice – especially in older mice – experts found that their neural connections were not only strengthened, but also rejuvenated, since microglial tissues began to work an order of magnitude faster and better. On the one hand, experience shows that the notorious rejuvenation of the brain is indeed possible, and on the other hand, it opens up to scientists an endless ocean of questions that remains to be solved.