A team of biochemistry engineers from the Cochrell University of Texas Graduate School of Engineering, together with colleagues from the University of Pennsylvania, presented a new study on the dysfunction of certain types of immune cells in patients diagnosed with HIV – and they found one very interesting relationship around one of the families of these immune cells in the context of the fight against the virus itself. In a recent article published in the science journal Science Immunology, an integrated team of scientists applied a whole range of sequential technologies and mass cytometry to identify this relationship.
This relationship revolves around the increased number of Tfh immune cells in the body of HIV-infected people and the lack of a normal response to fast-growing cells like CD4 + T, which are directly responsible for the process of killing viral cells in the body.
Scientists have found that in the vast majority of cases of HIV infection in patients, a significant increase in Tfh immune cells is observed, which at the same time ceases to function as expected, which means the absence of their reaction to irritant cells, and this in turn leads to the absence of a general immune response to HIV . The research team suggests that such a significant increase in the number of Tfh cells may be due to the “reformatting” of the work of other immune cells, but what exactly are we talking about does not indicate in this study – which, however, is only a matter of time!
Currently, specialists are trying to establish what other factors influence the increase in the number of Tfh immune cells and why their function is impaired during the development of the virus – all these potential answers will help to better understand the nature of HIV disease itself and provide a more complete picture of new potentially more effective therapies. In particular, the attention of specialists focuses on the central function of antibodies in the patient’s body.