News & Events
A New Approach to Cancer Immunotherapy Introduced
- May 3, 2020
- Posted by: Wiley M. Wagner
- Category: Science
The treatment of various types and directions of oncological diseases usually does not proceed as easily and quickly as doctors want – this is especially true for the so-called non-Hodgkin lymphoma, a particularly dangerous cancer that begins in lymphomas and affects the entire immune system. And today, a team of oncologists from the Lausanne Higher Polytechnic School in Switzerland presented their new development of genetic engineering, with the help of which they were able to literally reverse the process of infection of cells against themselves – by removing a specific internal gene that every person has in the immune system.
We are talking about a protein called cathepsin-C, which with non-Hodgkin’s lymphoma – as well as with some other types of cancer – gradually mutates, which determines a further increased release of B-cells, while dividing other types of proteins into fragments that serve as a kind of barrier between healthy and cancerous cells. However, cancer cells of lymphoma attach to CD4 + cells through an inherent process inherent to them and avoid CD8 + cells – the former allow them to grow, and the latter, on the contrary, interfere.
After several preliminary laboratory tests using individual particles of this protein, experts came to the conclusion that removing it from the immune field helps cancer cells to attach to CD8 + cells and avoid CD4 + cells, which ultimately leads to their destruction even before how they managed to sow many of their copies in the internal organs of patients. Thus, specialists have increased the level of effectiveness of the treatment of non-Hodgkin lymphoma to a qualitatively new level.
It is worth noting the fact that the cure for this type of cancer is most often associated with the use of immunotherapy – and therefore oncologists are in no hurry to declare that their method is absolutely universal. Additional tests are strictly necessary before such a format of treatment is considered indicative and begins its implementation in the international health system.